What are the side effects of Simparica?

We all want to protect our pets from fleas, ticks and the diseases they carry, but some treatments can come with nasty side effects.
Every good pet parent wants to keep fleas off his dog, but many worries about the side effects that can accompany various flea and tick treatments. Fortunately for conscientious dog moms and dads, Simparica offers a once-a-month chewable treatment that is FDA-approved and safe for Fido, taking the guesswork out of fighting fleas and ticks.
Like other oral treatments, Simparicaworks by entering a dog’s bloodstream immediately after ingestion. When fleas or ticks bite, they are exposed to its FDA-approved ingredient sarolaner, the insecticide, and acaricide that kills parasites fast. Sarolanerstarts fighting fleas within three hours and begins to kill ticks after 8 hours—including the lone star tick, black-legged tick, brown dog tick, American dog tick, and Gulf Coast tick. Because this ingredient works differently on invertebrates than mammals, however, Simparica for dogs has been proven safe during field trials.
Simparicaworks by impacting the nervous system of invertebrates such as fleas and ticks. The innovative formula disrupts gamma-aminobutyric acid (GABA) and glutamate receptors, which both play a role in nerve transmissions. GAGA-gated channels help to calm nerve transmissions, which sarolaner alters, creating an influx of nerve transmissions. At the same time, it opens glutamate-gated channels, which adds to the flood of nerve communications. The results are fatal for fleas and ticks but safe for mammals such as your dog.
Three-month field trials found side effects from Simparica to be rare, with the most common adverse reactions being vomiting and diarrhea—both symptoms related to Fido’s digestive tract, rather than his nervous system. In isolated cases, however, dogs displayed more serious reactions such as tremors, muscle twitching, and seizures. Simparica is available by prescription only, so discuss any history your dog has of seizure disorders with your veterinarian when determining the best flea and tick treatment for your pet.
In addition to killing fleas and several kinds of ticks, Simparicais effective in preventing and treating mange and ear mites. Thanks to its innovative formula, the treatment continues to work for 35 days, providing long-lasting relief from parasites and the diseases they carry. Simparica is available in different doses for dogs 2.8 pounds and over, but has not been evaluated for use in pregnant, breeding or nursing pets. Discuss Simparica chewable treats with your veterinarian when looking for a safe, effective way to arm your dog against biting parasites and the diseases they carry.
Comment(s)50
He is having profuse diarrhea, urinating constantly and he is supper agitated
My vet did not tell me anything about the side effects
Can I ask how long the diarrhea lasted? I gave my 6 month old pup this medication on Monday morning and he’s had diarrhea since yesterday (Tuesday) afternoon.
They put her on Phenobarbital to stop the seizures but cause her to be very wobbly and she’s been throwing up over the last two days and stopped eating today. How can I help of the manufacturer’s of Simparica responsible for causing so many dogs to experience these adverse and most likely permanent side effects.
It sure how it works on dogs but maybe do some research?
After a vet visit, he was put on a good gastro food and probiotics and he seems to be back to his old self. In his case it was all a digestion side effect but a nasty one also with diarrhea.
BUT...
I want to know, what was the size of the test group, and how many dogs had each side effect? Is there a way to find this out? And, is a 3 month trial really long enough for a drug that is basically an insecticide?
My pup has had zero adverse side effects to Simparica Trio and I hope that continues.
For those asking about the trials -- I found the information here https://www2.zoetisus.com/content/_assets/docs/Petcare/simparica-trio-pi.pdf?_ga=2.223688731.1016898103.1608045514-861822939.1608045514&_gac=1.160980559.1608045516.Cj0KCQiA2uH-BRCCARIsAEeef3m64ho1RNpYyKyE2TXamcOK-YEQbZcN9yaWL1OjRk_nlhnVZfLfDv8aApb9EALw_wcB
Few questions
- have you guys asked for these issues to be reported by the vet to company & FDA?
- how long does the symptoms last? A little concerned & worried about the little puppy
Additionally she is having urination problems. She goes like 50 times a day and it is long and slow. I told the vet about her first dose and they said "oh that's a good medication" and attributed her symptoms to her age and possibly a heart condition. Tonight after her second dose she is having significant tremors and now loss of balance. I am now CONVINCED it is from this medication and she will not be taking this nor any other flea meds for the rest of her life. It's not worth it. What a shame that we only research meds after something goes wrong. We should be able to take our vets advice. Rallye will make it through this.