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Common brand names

Single ingredient

  • Frontline for Dogs and Cats
  • PetArmor for Dogs and Cats

Combined ingredients

Generic products are available.

Uses of Fipronil

Fipronil is a broad-spectrum ectoparasiticide used to treat fleas, ticks, and lice in dogs and cats. The ticks treated will vary from region to region.

For dogs: Used to treat and prevent flea infestations, control flea allergy dermatitis and control ticks, sarcoptic mange, mites and biting lice.

For cats: Used to treat and prevent flea infestations, control flea allergy dermatitis and control biting lice. Marketed for the treatment of ticks on cats in some countries.

When combined with (S)-methoprene it is used to stop the development of ticks and fleas at the egg, larvae and pupae stages.

Method of application

Fipronil is administered externally as a topical/spot-on solution or spray.

Dosage and administration

Fipronil spot-on is sold as separate canine and feline formulas, with the specific dosage based on the animal’s body weight. Fipronil spray may be used on dogs or cats, but it is important you apply only as directed to prevent overdosing.

To protect against fleas, ticks and biting lice, Fipronil should be applied monthly. For protection against paralysis ticks (Australia), apply to dogs every two weeks. Do not apply more than once a month to cats.

Treatment for fleas and ticks with Fipronil may begin at any time of year. In areas where fleas and ticks are prevalent at all time, Fipronil may be used year-round.

Follow the package instructions carefully to ensure the products is applied where the animal cannot lick it off.

Do not apply to wet fur, and do not allow the animal to bathe or swim for 48 hours after application.

The uses and dosage of Fipronil may vary from product to product, so it is important to read the packaging carefully, even if you have used Fipronil on your pet previously.

Possible side effects

The most commonly reported side effect following treatment with Fipronil is skin reactions at the site of application. Less common side effects include signs of nervousness, depression, and vomiting.

Animals that lick the area of application may experience a brief period of excessive salivation.


For external use only, do not allow the animal to ingest.

Generally not recommended for use on cats under 8 weeks old or weighing less than 2 pounds (1 kg) – some spray formulas may be suitable for use on younger animals.

Generally not recommended for use on dogs under 8 weeks old or weighing less than 4 pounds (2 kg)  – some spray formulas may be suitable for use on younger animals.

Do not use on animals that are unwell, are undergoing treatment for, or are recovering from illness.

Fipronil is suitable for use with pregnant and lactating animals when used as directed.

Signs of toxicity

Toxicity from Fipronil can occur from incorrect topical dosing or from accidental ingestion, particularly when the animal licks the area of application.

The primary symptoms of intoxication with Fipronil include ataxia, hyperreactivity, tremors, cramps, convulsions, and seizures.

Other reported symptoms include twitching, nodding, aggression, sweating, nausea, lack of appetite, vomiting, headache, abdominal pain, dizziness, agitation and weakness.


Store in the original package. Store in a dry place. Store below 30°C/86°F. Flammable.


This information is provided for general reference only and is not intended to replace the packaging label or veterinary advice. This page may not include all side effects, uses, brand names or applications.


Fipronil drug information sheet
Fipronil Information Sheet

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